Monday, February 20, 2012

Pancreatic cancer: Trial drug MRK003 shows promise



Pancreatic cancer cellDoctors want to improve the prognosis of this aggressive cancer


Scientists say they may have found a new weapon against pancreatic cancer after promising early trial results of an experimental drug combination.
Giving the chemotherapy agent gemcitabine with an experimental drug called MRK003 sets off a chain of events that ultimately kills cancer cells, studies in mice show.
Patients are now testing the treatment to see if it will work for them.
The Cancer Research UK-funded trials are being carried out in Cambridge.
Father-of-two Richard Griffiths, 41, from Coventry, has been on the trial since being diagnosed with pancreatic cancer in May 2011.
"After six cycles of treatment, a scan showed the tumours had reduced and so I have continued with the treatment," he said.
"The trial gives you hope - I really feel I can do this with the science behind me."
Aggressive cancer
Cancer Research UK says it is prioritising research into pancreatic cancer because the survival rate still remains dismally low.
About 8,000 people in the UK are diagnosed with pancreatic cancer each year, and the disease is the fifth most common cause of cancer death in the UK.
Survival rates are very low in relation to other cancers, and the length of time between diagnosis and death is typically short, usually less than six months.
The most recent data for England show that about 16% of patients survive the disease beyond 12 months after diagnosis - prompting the need for new treatments.
Professor Duncan Jodrell, who is leading the trials at the University of Cambridge, said: "We're delighted that the results of this important research are now being evaluated in a clinical trial, to test whether this might be a new treatment approach for patients with pancreatic cancer, although it will be some time before we're able to say how successful this will be in patients."
In total, about 60 patients with advanced pancreatic cancer will be recruited for the first Phase I/II clinical trial.

Experts delay call on releasing controversial H5N1 work



Bird flu researchResearch into the H5N1 virus has to be carried out in highly controlled conditions


Experts have delayed a decision on whether controversial research into the H5N1 bird flu virus should be released.
It had been looking at how the work could be released while guarding against its abuse by bioterrorists.
But talks at the World Health Organization in Geneva decided more discussions were needed to see if it could be possible to publish in full.
One of the two journals which want to publish has already agreed to wait for talks to be complete.
Mutation fears
The controversy is centred on two research papers - one of which was submitted to Science, the other to another leading journal, Nature, last year.
They showed that the H5N1 virus could relatively easily mutate into a form that could spread rapidly among the human population.
The studies prompted the US National Security Advisory Board for Biotechnology (NSABB) to ask both journals last November to redact some sensitive parts of the research, which it believed could be used by terrorists to develop such a virus.

Analysis

These talks go to the heart of a fundamental debate over whether scientists should operate openly and publish all their findings - which is a basic principle of modern research - or whether some subjects are so sensitive that some key details should only be available to a carefully vetted audience.
The talks in Geneva have not resolved this.
The researchers passionately believe that the best way to tackle the threat of a pandemic is to understand how the virus can mutate, and that only by releasing their results in scientific journals will progress be made.
Ranged against them are experts in security who argue that too much information in the public domain will create another weapon for terrorists.
It's a highly sensitive dispute - the scientists fear that any kind of censorship will set a precedent of government control over their work.
So it's no surprise that another round of talks will be held in a couple of months, and in the meantime, research will remain on hold.
The request caused outcry among some scientists who believed that it was an infringement of academic freedom.
Some pointed out that the scientists had given presentations about their work at conferences and the details were already widely circulated, so redaction would have little purpose.
The scientists who carried out the research, and the journals concerned, have been considering the request and listening to suggestions as to how the research results could be redacted in the scientific journals, but distributed to bona fide researchers who urgently need the information.
The information is vital to develop a vaccine to any human form of bird flu, and it would enable surveillance teams to see if the bird flu virus was mutating into a form that could be transmissible to humans.
But such efforts have been put on hold for four months as governments, scientists and the journals decide what to do.
The Geneva meeting of 22 scientists and journal representatives agreed that publishing only parts of the research would not be helpful, because they would not give the full context of a complete paper.
It agreed to extend a temporary moratorium on research using lab-modified H5N1 viruses, but also recognised that research on naturally occurring virus "must continue".
'Critical importance'
Dr Keji Fukada, assistant director-general of health security and environment for the WHO, said: "Given the high death rate associated with this virus - 60% of all humans who have been infected have died - all participants at the meeting emphasised the high level of concern with this flu virus in the scientific community and the need to understand it better with additional research.
"The results of this new research have made it clear that H5N1 viruses have the potential to transmit more easily between people underscoring the critical importance for continued surveillance and research with this virus."
Dr Fukada added: "There is a preference from a public health perspective for full disclosure of the information in these two studies. However there are significant public concern surrounding this research that should first be addressed."
Experts will now look at what information is already in the public domain and how that relates to the contents of these research papers.
A further meeting is likely to happen in a couple of months' time.
Nature has said it is happy to wait - if there is a chance it will able to publish in full.
Science's editor Dr Bruce Alberts, had previously said it also wanted to publish full details of the work, unless progress was made on how to circulate details of the findings to scientists.

Twickenham film studios set to close



Meryl Streep as Margaret Thatcher in The Iron LadyPost-production of The Iron Lady was completed at Twickenham


Twickenham Film Studios, recently used for The Iron Lady and My Week with Marilyn, has gone into administration.
The renowned studio, which was due to celebrate its centenary next year, will be wound down between now and June.
Gerald Krasner, who is handling the administration, said the the business had lost money over the past three years.
"I doubt it will be retained as a film studio," he said. Half of the 17 employees have already left.
The remainder are working their notice, Mr Krasner added.
"We are selling it on," he told the BBC News website. "Everyone will then be paid in full."
Classic movies shot at Twickenham, which opened in 1913, include include Sherlock Holmes film The Missing Rembrandt, made in the 1930s, and the Beatles films Help and A Hard Day's Night.
Roman Polanski's Repulsion, Alfie starring Michael Caine and Saturday Night and Sunday Morning also made use of its facilities.
More recently War Horse and Horrid Henry: The Movie were made there, while director Phyllida Lloyd completed post-production on The Iron Lady at the historic studios.
The Beatles were presented with a Radio Caroline First Birthday Award at Twickenham Studios in the 1960s
Its old viewing theatre and wardrobe department was also seen in My Week with Marilyn, starring Michelle Williams and Kenneth Branagh.
"I think it is a real shame that Twickenham's closing," said key grip Rupert Lloyd Parry, who worked on both The Iron Lady and My Week with Marilyn. "It's one of our older studios.
"It's nice when you work where you feel like there's a real sort of tradition of the British film industry. It's like working at Ealing, places like that.
"The film industry is buoyant at the moment, there is work coming in. There doesn't seem like there is any reason for it to shut."
Built on the site of a former ice rink, St Margaret's Studios was set up in 1913 by Dr Ralph Jupp and was the largest studio in the UK at the time.
It was re-named Twickenham Film Studios in 1929 by its then-owners Julius Hagen and Leslie Hiscott.

China eases foreign film restrictions



Kung Fu Panda advertising outside a Beijing cinemaKung Fu Panda 2 was the second highest-grossing film of 2011 in China

China has agreed to ease restrictions on the number of foreign films shown there, and to increase the amount film studios can make from ticket sales.

A quota of 20 foreign movies, which are mostly US exports, remains. A further 14 Imax or 3D films will be allowed.
The Motion Picture Association of America said the "landmark" deal - brokered with the US - would allow 50% more Hollywood films into China.
Chinese box office receipts topped $2bn (£1.26bn) last year, US officials said.
Vendor selling pirated DVDs in ChinaPiracy has affected the sale of Hollywood movies in China
As part of the agreement, the amount of revenue foreign movies are allowed to collect from movies distributed in China will be increased from about 13% to 25% of ticket revenue.
Announcing the deal at the end of last week's visit of Chinese Vice-President Xi Jinping, US Vice-President Joe Biden said it would "make it easier than ever before for US studios and independent film-makers to reach the fast-growing Chinese audience".
He said the move would support "thousands of American jobs in and around the film industry".
"At the same time, Chinese audiences will have access to more of the finest films made anywhere in the world," he added.
The US movie industry has long complained that the limit fuelled demand for pirated copies of films, which are widely available in China.
In December 2009, the World Trade Organization ruled that China should allow more imported films to be released in cinemas but little had changed before Friday's announcement.
"By promoting the growth of a legitimate marketplace for US movies in China, this agreement will also complement efforts to fight movie piracy and help protect the jobs of workers in both countries, whose livelihoods are dependent on a healthy entertainment industry," MPAA president Chris Dodd said.

Top grossing films in China in 2011

  • Transformers 3: The Dark Side of the Moon - $170m (£107.2m)
  • Kung Fu Panda 2 - $98m (£61.8m)
  • Pirates of the Caribbean: On Stranger Tides - $76m (£47.9m)
Source: Artisan Gateway
According to tracking firm Artisan Gateway, China had 10,500 cinema screens by the end of 2011. It said the figure could top 13,000 by the end of this year.
By comparison, the US has 40,000 cinema screens.
During Mr Xi's visit to California, US film giant DreamWorks Animation announced a $330m (£210m) joint venture with China.
Oriental DreamWorks will give the company further access to Chinese cinema-goers who have fallen in love with films including the studio's Kung Fu Panda 2.